effects of acute administration of acetyl-l-carnitine on hemodynamic function and infarct size in ischemic-reperfused isolated heart

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Effects of Acetyl-L-Carnitine on Cardiac Arrhythmias and Infarct Size in Ischemic-Reperfused Isolated Rat Heart

Objective(s) This study aimed to examine whether acetyl-L-carnitine (ALC) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. Materials and Methods The isolated hearts were mounted on a Langendorff apparatus then perfused by a modified Krebs-Henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched K...

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effects of acetyl-l-carnitine on cardiac arrhythmias and infarct size in ischemic-reperfused isolated rat heart

objective(s) this study aimed to examine whether acetyl-l-carnitine (alc) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. materials and methods the isolated hearts were mounted on a langendorff apparatus then perfused by a modified krebs-henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched kreb...

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Effects of Acetyl-L-Carnitine on Cardiac Arrhythmias and Infarct Size in Ischemic-Reperfused Isolated Rat Heart

Objective(s) This study aimed to examine whether acetyl-L-carnitine (ALC) was able to reduce cardiac arrhythmias and infarct size in the ischemic-reperfused isolated rat heart. Materials and Methods The isolated hearts were mounted on a Langendorff apparatus then perfused by a modified Krebs-Henseleit solution during 30 min regional ischemia and 120 min reperfusion (control) or by enriched Kreb...

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Effects of L-Carnitine on Cardiac Apoptosis in Ischemic- Reperfused Isolated Rat Heart

     Carnitine is a vital biologic substance for transporting fatty acids into myocytes. It also facilitates fatty acids β-oxidation for energy production. In this study, effects of L-carnitine (L-Car) on apoptosis in the ischemic isolated rat heart were investigated. Male Sprague-Dawley rats were divided into four groups and anesthetized by sodium pentobarbital. The heart was removed and mount...

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Comparison between the effects of L-Carnitine and Acetyl-L-Carnitine on myocardial infarction size in ischemic heart

Introduction: In the present study, potential differences between the effects of L-carnitine (LC) and acetyl-Lcarnitine (ALC) on ischemia/reperfusion (I/R)-induced myocardial infarction size were investigated. Methods: Male Wistar rats were randomly divided into five groups and then anesthetized by sodium pentobarbital. Hearts of the animals were removed and quickly mounted on a Langendorff ...

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effects of l-carnitine on cardiac apoptosis in ischemic- reperfused isolated rat heart

carnitine is a vital biologic substance for transporting fatty acids into myocytes. it also facilitates fatty acids β-oxidation for energy production. in this study, effects of l-carnitine (l-car) on apoptosis in the ischemic isolated rat heart were investigated. male sprague-dawley rats were divided into four groups and anesthetized by sodium pentobarbital. the heart was removed and mounted on...

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Journal title:
research in pharmaceutical sciences

جلد ۷، شماره ۵، صفحات ۰-۰

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